Hawach Scientific Co., Ltd

-80°C mini freeze dryer machine, digital display

This -80°C mini freeze dryer machine is an option for -50°C vacuum freeze drying machine. Compared to the -50 series, the -80 series has lower condensation temperature — -80 degrees centigrade, and higher vacuum degree — <10Pa.

Technical parameters of -80°C mini freeze dryer machine

-80°C laboratory lyophilizer, LCD display

An upgraded version of -56°C lab scale freeze dryer, Hawach’s -80°C laboratory lyophilizer has cold trap temperature lower than -80 degrees centigrade and is equipped with dual refrigerating systems.

Technical parameters of -80°C laboratory lyophilizer

LFD80-12 series

LFD80-18 series

-80°C pilot scale lyophilizer, electronic heating; LCD display

Hawach’s -80°C pilot scale lyophilizer is another choice for -60°C tray freeze dryer. Besides its lower condensation temp -80°C, this lyophilizer also has dual condensers.

Technical parameters of -80°C pilot scale lyophilizer

-80°C in-situ industrial lyophilizer, electronic heating; LCD display

-80°C in-situ industrial lyophilizer also differs from its -55°C version regarding temperature and refrigeration system.

Technical parameters of -80°C in-situ industrial lyophilizer

Several parameters that should be paid attention to when purchasing freeze dryer

1. Freeze-dried areaUsers should determine how much freeze-drying area to use according to their own needs. Hawach’s ordinary -80°C mini freeze dryer machine, FD-80 -A has drying area of 0.12㎡. For example, for each batch of products that require lyophilization of 1.2 kg (liter) of liquid, use the material tray to load the material, each tray is loaded with 10㎜ thick, then the load area of the freeze-dried board layer can be calculated:A (Area, ㎡) = V (Volume, m3) / H (Height, m) = 0.0012m3 / 0.01m = 0.12㎡It is necessary to select a freeze dryer with a layer load area of 0.12㎡.

2. Cold trap temperatureCold trap is a device to capture water in the freeze-drying process. Theoretically, the lower the temperature of the cold trap, the stronger the water-capturing ability. The temperature of the cold trap of the laboratory lyophilizer mainly has several grades such as about -45 ℃, about -60 ℃, and about -80 ℃. Freeze-drying with the first grade temperature is suitable for some products that are easy to freeze-dry; the second for most products, and the third for special products.

3. Cooling rateThe cooling rate reflects the cooling capacity of the refrigeration system. Under no-load conditions, the cold trap temperature should reach the minimum temperature specified in the index within 1 hour. For example, for a freeze dryer with a cold trap temperature ≤-80 ° C,(Hawach’s low cost freeze dryer -80 series), the machine will start timing when the refrigeration is turned on, and the time for the cold trap temperature to reach -60 ° C shall not exceed 1 hour.

4. Temperature uniformity and flatness of the material shelfTemperature uniformity and flatness of the shelf have a great influence on product quality uniformity. The temperature control of the shelf includes heater type and intermediate fluid type. And the latter is better regarding the two indicators. The cooling and heating are achieved through the circulation of the intermediate fluid in the fluid channel inside the shelf, so the temperature of the layer is uniform. The temperature control of the shelf of the bell-type freeze dryer (Hawach’s pilot scale lyophilizer -80 series, for example) is basically a heater, and the temperature consistency of the shelf is slightly worse. But in general, the temperature difference of the shelf for medicine should be controlled within ± 1.5 ℃, and the temperature difference within the plate should be ± l ℃.

5. Control systemThe control system and functions of freeze dryers are different. For the laboratory lyophilizer, it is mainly used in the exploration of lyophilization process and a small amount of trial production. Therefore, the control system should be able to display and automatically record the parameters of the freeze-drying process in real time; able to set, modify and effectively execute the freeze-drying process program; have a USB interface for data collection and storage.